This Week in Startups

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This Week in Startups

This Week in Startups

Skaber: Jason Calacanis

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

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1419 episoder
5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

This Week In Startups is made possible by:


IM8 Health - https://IM8health.com/TWIST
Every - Every.io
Sentry - https://...

2026-05-09 02:40:11 01:12:00
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The end of Venture Capital? (VC Roundtable) | E2285

The end of Venture Capital? (VC Roundtable) | E2285

This Week In Startups is made possible by:
Grasshopper Bank - https://grasshopper.bank/twist
PaperOS - https://paperos.com/twist
Lin...

2026-05-07 01:20:41 01:23:37
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Naval's GP, Ankur Nagpal, Breaks Down The Viral “USVC” Fund | E2284

Naval's GP, Ankur Nagpal, Breaks Down The Viral “USVC” Fund | E2284

This Week In Startups is made possible by:


Render - render.com/twist
Vanta - vanta.com/twist
Northwest Registered Agen...

2026-05-05 02:08:21 01:38:10
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Can an AI Agent Legally Own a Company? Christian van der Henst's Wild Experiment| E2283

Can an AI Agent Legally Own a Company? Christian van der Henst's Wild Experiment| E2283

This Week In Startups is made possible by:
Pilot - https://pilot.com/twist
Shopify - https://shopify.com/twist
Grasshopper Bank - ht...

2026-05-02 00:53:02 01:10:05
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Mastering AI Video Marketing w/ Magnific CEO Joaquín Cuenca Abela | AI Basics

Mastering AI Video Marketing w/ Magnific CEO Joaquín Cuenca Abela | AI Basics

The TWiST AI Basics series is made possible by Google Cloud!Check out Google Cloud’s new report, “Future of AI: Perspectives on generative media for s...

2026-04-30 19:32:39 00:22:34
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The $10M+ Bet on a Beanie That Reads Your Brain | Sabi & the Future of BCI | E2282

The $10M+ Bet on a Beanie That Reads Your Brain | Sabi & the Future of BCI | E2282

This Week In Startups is made possible by:
Render - https://Render.com/TWIST
Northwest Registered Agent - https://NorthwestRegisteredAgent...

2026-04-29 22:53:36 00:55:43
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To the left of this of thumbnail i want to add a chinese flag to the left destroying the meta logo. because the title is  China Kills Meta / Manus Deal (Story Of The Year) | E2281

To the left of this of thumbnail i want to add a chinese flag to the left destroying the meta logo. because the title is China Kills Meta / Manus Deal (Story Of The Year) | E2281

This Week In Startups is made possible by:
IM8 Health - IM8health.com/twist
Sentry - Sentry.io/twist
Deel - Deel.com/twistPlaud - ht...

2026-04-28 02:11:09 00:53:03
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Naval’s $500 VC fund, the Maduro Polymarket scandal, and NYT defends theft and murder | E2280

Naval’s $500 VC fund, the Maduro Polymarket scandal, and NYT defends theft and murder | E2280

This Week In Startups is made possible by:
Northwest Registered Agent - https://northwestregisteredagent.com/twist
LinkedIn Jobs - https:...

2026-04-25 19:57:10 00:50:20
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The Defense Tech Startup YC Kicked Out of a Meeting is Now Arming America | E2280

The Defense Tech Startup YC Kicked Out of a Meeting is Now Arming America | E2280

This Week In Startups is made possible by:
Northwest Registered Agent - https://northwestregisteredagent.com/twist
Render - https://rende...

2026-04-25 03:21:02 00:59:15
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SpaceX and Cursor team up to topple Claude Code | E2279

SpaceX and Cursor team up to topple Claude Code | E2279

This Week In Startups is made possible by:

LinkedIn Jobs - linkedIn.com/twist
Grasshopper Bank - grasshopper.bank/twist
Notio...

2026-04-23 01:07:37 01:13:29
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Why Your Company Should Own Its AI Model | E2278

Why Your Company Should Own Its AI Model | E2278

This Week In Startups is made possible by:
Quo - https://quo.com/TWiST Vanta -
https://vanta.com/twist
Pilot - https://pilot.com/t...

2026-04-21 03:43:35 01:16:59
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3D-Printed Homes for $99K: ICON’s Jason Ballard on the future of housing | E2277

3D-Printed Homes for $99K: ICON’s Jason Ballard on the future of housing | E2277

This Week In Startups is made possible by:IM8 Health - https://IM8health.com/twist Grasshopper Bank - https://grasshopper.bank/twist Northwest Registe...

2026-04-18 03:46:02 01:47:05
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This 22-Year-Old Built TikTok for Mobile Games, and It’s Growing Fast | E2276

This 22-Year-Old Built TikTok for Mobile Games, and It’s Growing Fast | E2276

This Week In Startups is made possible by:
LinkedIn Jobs - LinkedIn.com/twist Every.io - every.io Render - render.com/twist
Today’s show:<...

2026-04-16 01:02:25 01:02:46
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Bittensor’s (alleged) $10M rug pull (feat. Mark Jeffrey) | E2275

Bittensor’s (alleged) $10M rug pull (feat. Mark Jeffrey) | E2275

This Week In Startups is made possible by:
Sentry - https://sentry.io/twist
Deel - https://deel.com/twist Netsuite -
https://netsu...

2026-04-14 02:38:01 01:18:38
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Bittensor Drama! TAO down 15%! | E2274

Bittensor Drama! TAO down 15%! | E2274

This Week In Startups is made possible by:


Pilot - https://pilot.com/TWIST
Squarespace -https://squarespace.com/TWIST
...

2026-04-11 03:16:21 01:21:54
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Anthropic’s Mythos is a cyber-weapon, so you can’t have it | E2273

Anthropic’s Mythos is a cyber-weapon, so you can’t have it | E2273

Anthropic just built a model so dangerous, they’re not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss...

2026-04-09 02:01:41 01:16:48
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3 AI Agents That Actually Replaced Human Jobs | E2272

3 AI Agents That Actually Replaced Human Jobs | E2272

Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top...

2026-04-07 02:59:18 01:19:09
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AI Rebuilt Every YC W26 Startup. Should Founders Be Scared? | E2271

AI Rebuilt Every YC W26 Startup. Should Founders Be Scared? | E2271

This Week In Startups is made possible by:


Deel - deel.com/twist
Grasshopper Bank - grasshopper.bank/twist
Render - re...

2026-04-04 01:26:05 01:20:52
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How 3 CEOs Use AI to Run $10B in Companies | This Week in AI

How 3 CEOs Use AI to Run $10B in Companies | This Week in AI

This Week in AI, JCal sits down with three CEOs building the infrastructure, intelligence, and interfaces for the next era of AI: Jeremy Fraenkel (CEO...

2026-04-02 17:33:18 00:30:10
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Venture Roundtable: SpaceX IPO, AI's PR Crisis, and the Defense Tech Bubble | E2270

Venture Roundtable: SpaceX IPO, AI's PR Crisis, and the Defense Tech Bubble | E2270

This Week In Startups is made possible by:
PaperOS - https://PaperOS.com/twist
Northwest Registered Agent- https://northwestregisteredagen...

2026-04-02 01:48:23 01:28:07
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The 5-Step Framework for AI Agents That Improve While You Sleep | E2269

The 5-Step Framework for AI Agents That Improve While You Sleep | E2269

This Week In Startups is made possible by:

Quo - https://quo.com/TWiST
LinkedIn Jobs - https://LinkedIn.com/twist
Iru - https...

2026-03-31 02:18:59 01:27:14
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The $60 billion resource hiding in space, and the start trying to mine it (feat. Matt Gialich, Astroforge) | E2268

The $60 billion resource hiding in space, and the start trying to mine it (feat. Matt Gialich, Astroforge) | E2268

This Week In Startups is made possible by:


Wispr Flow - https://wisprflow.ai/twist
Circle - http://circle.so/twist
Dee...

2026-03-28 00:40:54 01:39:16
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This Bittensor Subnet Could Cut Drug Discovery Costs in HALF | E2267

This Bittensor Subnet Could Cut Drug Discovery Costs in HALF | E2267

This Week In Startups is made possible by:
Luma AI - https://lumalabs.ai/twist
Every.io -  https://every.io
Lemon.io - https://Lemon...

2026-03-26 01:30:13 01:12:53
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$2.5B Chip Heist, The Future of American AI, and Purpose-Built Robots | This Week in AI Ep 6

$2.5B Chip Heist, The Future of American AI, and Purpose-Built Robots | This Week in AI Ep 6

This Week in AI sneak peak! If you enjoy the episode find us on Spotify, Apple podcasts and YouTube by looking up "This Week in AI" or by going to thi...

2026-03-25 23:01:51 01:15:24
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Compliance Startup Scandal... Is Delve Guilty? | E2266

Compliance Startup Scandal... Is Delve Guilty? | E2266

This Week In Startups is made possible by:

Northwest Registered Agent - https://northwestregisteredagent.com/twist
LinkedIn Jobs -...

2026-03-24 16:00:27 01:26:44
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The Drone Company Everyone Thought Was Illegal (Now Worth $4B+) | E2265

The Drone Company Everyone Thought Was Illegal (Now Worth $4B+) | E2265

This Week In Startups is made possible by:

Northwest Registered Agent - https://www.northwestregisteredagent.com/twist


2026-03-20 22:26:37 01:38:38
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How Robinhood became a $68B company w/ Vlad Tenev

How Robinhood became a $68B company w/ Vlad Tenev

This Week In Startups is made possible by:


Deel - https://deel.com/twist
LinkedIn Jobs - https://LinkedIn.com/twist.
I...

2026-03-18 20:20:17 00:49:41
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Are Brain-Computer Interfaces Actually Ready for Humans?

Are Brain-Computer Interfaces Actually Ready for Humans?

This Week In Startups is made possible by:
Caldera + Lab - https://CalderaLab.com/TWIST
Northwest Registered Agent - https://northwestregi...

2026-03-17 00:34:08 01:13:45
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One Genius Rule That Made This Coffee Brand Famous | EP 2262

One Genius Rule That Made This Coffee Brand Famous | EP 2262

Legendary British ad man Rory Sutherland invented a fake business on a podcast, a coffee shop appealing to the busy commuter called “Flat White or F**...

2026-03-14 02:27:07 01:30:27
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The Global Expansion of Self-Driving Vehicles

The Global Expansion of Self-Driving Vehicles

This Week In Startups is made possible by:


Circle - http://circle.so/twist


Sentry - http://Sentry.io

2026-03-11 22:55:38 01:09:18
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How agents will change banking forever | E2260

How agents will change banking forever | E2260

This Week In Startups is made possible by:
Northwest Registered Agent - ⁠⁠northwestregisteredagent.com/twist⁠⁠
Quo - ⁠⁠quo.com/TWiST⁠⁠

2026-03-10 02:06:00 01:00:38
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Wisdom of the $TAO: the future is decentralized AI

Wisdom of the $TAO: the future is decentralized AI

This Week In Startups is made possible by:
Every Banking - https://Every.io
https://Lemon.io - Lemon.io/twist
Wispr Flow - https://w...

2026-03-07 00:19:04 01:08:26
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Is Anthropic Making the Biggest Mistake in AI History | E2258

Is Anthropic Making the Biggest Mistake in AI History | E2258

This Week In Startups is made possible by:
Plaud - Plaud.ai/twist
LinkedIn Jobs - https://LinkedIn.com/twist.
Deel - https://deel.co...

2026-03-05 01:26:06 01:20:55
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How the OpenClaw foundation bullet-proofed its future (w/Dave Morin) | E2257

How the OpenClaw foundation bullet-proofed its future (w/Dave Morin) | E2257

This Week In Startups is made possible by:Circle — http://circle.so/twistHubspot Creators — http://clickhubspot.com/twist2Uber AI Solutions — http://u...

2026-03-03 01:33:43 01:14:43
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The Biggest Private Funding Round in History | E2256

The Biggest Private Funding Round in History | E2256

This Week In Startups is made possible by:
Deel - http://deel.com/twist
Wispr Flow - https://wisprflow.ai/twist
Luma AI - https://lu...

2026-02-28 01:44:30 01:20:17
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Behind the Scenes with an early OpenClaw contributor! | E2252

Behind the Scenes with an early OpenClaw contributor! | E2252

This Week In Startups is made possible by:


Lemon IO - https://Lemon.io/twist
Every.io - https://every.io
Sentry.io- h...

2026-02-26 02:29:31 01:22:11
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Kill Your Startup’s Knowledge Chaos with OpenClaw (with Oliver Henry and Jeff Weisbein) | E2254

Kill Your Startup’s Knowledge Chaos with OpenClaw (with Oliver Henry and Jeff Weisbein) | E2254

This Week In Startups is made possible by:Caldera Lab - [calderalab.com/twist](https://calderalab.com/twist)Iru - [iru.com](http://Iru.com/twist)Linke...

2026-02-24 02:20:17 01:18:57
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We Asked 3 Experts How to Get More Value out of OpenClaw | E2253

We Asked 3 Experts How to Get More Value out of OpenClaw | E2253

This Week In Startups is made possible by:
Gusto - https://Gusto.com/twist
Circle - https://circle.so/twist
Northwest Registered Age...

2026-02-21 01:07:57 01:08:36
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When Will Openclaw go Mainstream? | E2252

When Will Openclaw go Mainstream? | E2252

This Week In Startups is made possible by:


Gusto - Try Gusto today and get 3 months free at gust.com/twist


Cru...

2026-02-19 03:11:39 01:02:26
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Will OpenAI Tank OpenClaw? | E2251

Will OpenAI Tank OpenClaw? | E2251

Will OpenAI Tank OpenClaw? | E2251
This Week In Startups is made possible by:
Northwest Registered Agent - https://www.northwestregistered...

2026-02-17 04:42:08 01:26:33
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